diff --git a/Directory.Build.props b/Directory.Build.props
index 786ac99f6db..c2d9e2ee336 100644
--- a/Directory.Build.props
+++ b/Directory.Build.props
@@ -11,6 +11,7 @@
     <Copyright>$(CopyrightNetFoundation)</Copyright>
     <PackageLicenseExpression>MIT</PackageLicenseExpression>
     <PackageProjectUrl>https://github.com/dotnet/winforms</PackageProjectUrl>
+    <NetFxTFM>net481</NetFxTFM>
     <CheckForOverflowUnderflow>false</CheckForOverflowUnderflow>
     <LangVersion Condition="'$(LangVersion)' == ''">preview</LangVersion>
     <ImplicitUsings>enable</ImplicitUsings>
diff --git a/pkg/Microsoft.Private.Windows.Core/Microsoft.Private.Windows.Core.Package.csproj b/pkg/Microsoft.Private.Windows.Core/Microsoft.Private.Windows.Core.Package.csproj
index 18a54905c93..128bdf8f7a4 100644
--- a/pkg/Microsoft.Private.Windows.Core/Microsoft.Private.Windows.Core.Package.csproj
+++ b/pkg/Microsoft.Private.Windows.Core/Microsoft.Private.Windows.Core.Package.csproj
@@ -5,7 +5,7 @@
   -->
 
   <PropertyGroup>
-    <TargetFramework>net472</TargetFramework>
+    <TargetFramework>$(NetFxTFM)</TargetFramework>
 
     <!-- Suppress some nuget warnings that are breaking our build until https://github.com/dotnet/arcade/issues/4337 is resolved -->
     <NoWarn>$(NoWarn);NU5100;NU5131;NU5128</NoWarn>
@@ -49,8 +49,8 @@
 
   <PropertyGroup>
     <_SourceProjectName>Microsoft.Private.Windows.Core</_SourceProjectName>
-    <_SourceRefDir>$(ArtifactsObjDir)$(_SourceProjectName)\$(Configuration)\net472\ref\</_SourceRefDir>
-    <_SourceBinDir>$(ArtifactsBinDir)$(_SourceProjectName)\$(Configuration)\net472\</_SourceBinDir>
+    <_SourceRefDir>$(ArtifactsObjDir)$(_SourceProjectName)\$(Configuration)\$(NetFxTFM)\ref\</_SourceRefDir>
+    <_SourceBinDir>$(ArtifactsBinDir)$(_SourceProjectName)\$(Configuration)\$(NetFxTFM)\</_SourceBinDir>
 
     <!-- Call custom target when creating the package -->
     <TargetsForTfmSpecificContentInPackage>$(TargetsForTfmSpecificContentInPackage);AddPackageContent</TargetsForTfmSpecificContentInPackage>
@@ -59,8 +59,8 @@
   <!-- Include implementation and reference assemblies in the package -->
   <Target Name="AddPackageContent">
     <ItemGroup>
-      <TfmSpecificPackageFile Include="$(_SourceBinDir)$(_SourceProjectName).dll" PackagePath="lib/net472" />
-      <TfmSpecificPackageFile Include="$(_SourceRefDir)$(_SourceProjectName).dll" PackagePath="ref/net472" />
+      <TfmSpecificPackageFile Include="$(_SourceBinDir)$(_SourceProjectName).dll" PackagePath="lib/$(NetFxTFM)" />
+      <TfmSpecificPackageFile Include="$(_SourceRefDir)$(_SourceProjectName).dll" PackagePath="ref/$(NetFxTFM)" />
     </ItemGroup>
   </Target>
 
diff --git a/src/System.Private.Windows.Core/src/Microsoft.Private.Windows.Core.csproj b/src/System.Private.Windows.Core/src/Microsoft.Private.Windows.Core.csproj
index 155e6d193a3..62d59e69f9e 100644
--- a/src/System.Private.Windows.Core/src/Microsoft.Private.Windows.Core.csproj
+++ b/src/System.Private.Windows.Core/src/Microsoft.Private.Windows.Core.csproj
@@ -2,7 +2,7 @@
 
   <PropertyGroup>
     <AssemblyName>Microsoft.Private.Windows.Core</AssemblyName>
-    <TargetFrameworks>net472</TargetFrameworks>
+    <TargetFrameworks>$(NetFxTFM)</TargetFrameworks>
     <AllowUnsafeBlocks>true</AllowUnsafeBlocks>
     <Nullable>enable</Nullable>
     <!--
diff --git a/src/System.Windows.Forms.Design/tests/UnitTests/System.Windows.Forms.Design.Tests.csproj b/src/System.Windows.Forms.Design/tests/UnitTests/System.Windows.Forms.Design.Tests.csproj
index ea4bcf42913..7dec9072b73 100644
--- a/src/System.Windows.Forms.Design/tests/UnitTests/System.Windows.Forms.Design.Tests.csproj
+++ b/src/System.Windows.Forms.Design/tests/UnitTests/System.Windows.Forms.Design.Tests.csproj
@@ -57,10 +57,10 @@
 
   <ItemGroup>
     <Reference Include="AxInterop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.WMPLib.dll</HintPath>
     </Reference>
     <Reference Include="Interop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.WMPLib.dll</HintPath>
     </Reference>
   </ItemGroup>
 
diff --git a/src/test/integration/WinformsControlsTest/WinformsControlsTest.csproj b/src/test/integration/WinformsControlsTest/WinformsControlsTest.csproj
index 9b23d3a3c6b..4d6c620dfad 100644
--- a/src/test/integration/WinformsControlsTest/WinformsControlsTest.csproj
+++ b/src/test/integration/WinformsControlsTest/WinformsControlsTest.csproj
@@ -131,10 +131,10 @@
 
   <ItemGroup>
     <Reference Include="AxInterop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.WMPLib.dll</HintPath>
     </Reference>
     <Reference Include="Interop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.WMPLib.dll</HintPath>
     </Reference>
   </ItemGroup>
 
diff --git a/src/test/unit/.NET Framework/AxHosts/AxHosts.csproj b/src/test/unit/.NET Framework/AxHosts/AxHosts.csproj
index 9c532cb7092..027c86ad58b 100644
--- a/src/test/unit/.NET Framework/AxHosts/AxHosts.csproj	
+++ b/src/test/unit/.NET Framework/AxHosts/AxHosts.csproj	
@@ -2,7 +2,7 @@
 
   <PropertyGroup>
     <OutputType>WinExe</OutputType>
-    <TargetFramework>net472</TargetFramework>
+    <TargetFramework>$(NetFxTFM)</TargetFramework>
     <Nullable>enable</Nullable>
     <UseWindowsForms>true</UseWindowsForms>
     <LangVersion>10</LangVersion>
@@ -95,4 +95,4 @@
     </ItemGroup>
   </Target>
 
-</Project>
\ No newline at end of file
+</Project>
diff --git a/src/test/unit/.NET Framework/UnsupportedTypes/UnsupportedTypes.csproj b/src/test/unit/.NET Framework/UnsupportedTypes/UnsupportedTypes.csproj
index 74cd3d27348..9e3bacab568 100644
--- a/src/test/unit/.NET Framework/UnsupportedTypes/UnsupportedTypes.csproj	
+++ b/src/test/unit/.NET Framework/UnsupportedTypes/UnsupportedTypes.csproj	
@@ -2,7 +2,7 @@
 
   <PropertyGroup>
     <OutputType>Library</OutputType>
-    <TargetFramework>net472</TargetFramework>
+    <TargetFramework>$(NetFxTFM)</TargetFramework>
     <Nullable>disable</Nullable>
     <UseWindowsForms>true</UseWindowsForms>
     <LangVersion>preview</LangVersion>
@@ -18,4 +18,4 @@
     <IsTestUtilityProject>true</IsTestUtilityProject>
   </PropertyGroup>
 
-</Project>
\ No newline at end of file
+</Project>
diff --git a/src/test/unit/System.Windows.Forms/ComDisabled/ComDisabled.Tests.csproj b/src/test/unit/System.Windows.Forms/ComDisabled/ComDisabled.Tests.csproj
index 840a3cdaf98..3d8b61a8a8b 100644
--- a/src/test/unit/System.Windows.Forms/ComDisabled/ComDisabled.Tests.csproj
+++ b/src/test/unit/System.Windows.Forms/ComDisabled/ComDisabled.Tests.csproj
@@ -27,19 +27,19 @@
 
   <ItemGroup>
     <Reference Include="AxInterop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.WMPLib.dll</HintPath>
     </Reference>
     <Reference Include="Interop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.WMPLib.dll</HintPath>
     </Reference>
   </ItemGroup>
 
   <ItemGroup>
     <Reference Include="AxInterop.SystemMonitor">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.SystemMonitor.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.SystemMonitor.dll</HintPath>
     </Reference>
     <Reference Include="Interop.SystemMonitor">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.SystemMonitor.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.SystemMonitor.dll</HintPath>
     </Reference>
   </ItemGroup>
 
diff --git a/src/test/unit/System.Windows.Forms/System.Windows.Forms.Tests.csproj b/src/test/unit/System.Windows.Forms/System.Windows.Forms.Tests.csproj
index 356d903a9cc..ee45f45225f 100644
--- a/src/test/unit/System.Windows.Forms/System.Windows.Forms.Tests.csproj
+++ b/src/test/unit/System.Windows.Forms/System.Windows.Forms.Tests.csproj
@@ -47,34 +47,34 @@
 
   <ItemGroup>
     <Reference Include="AxInterop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.WMPLib.dll</HintPath>
     </Reference>
     <Reference Include="Interop.WMPLib">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.WMPLib.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.WMPLib.dll</HintPath>
     </Reference>
   </ItemGroup>
 
   <ItemGroup>
     <Reference Include="AxInterop.SystemMonitor">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.SystemMonitor.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.SystemMonitor.dll</HintPath>
     </Reference>
     <Reference Include="Interop.SystemMonitor">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.SystemMonitor.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.SystemMonitor.dll</HintPath>
     </Reference>
   </ItemGroup>
 
   <ItemGroup>
     <Reference Include="AxInterop.SHDocVw">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\AxInterop.SHDocVw.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\AxInterop.SHDocVw.dll</HintPath>
     </Reference>
     <Reference Include="Interop.SHDocVw">
-      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\net472\Interop.SHDocVw.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\AxHosts\$(Configuration)\$(NetFxTFM)\Interop.SHDocVw.dll</HintPath>
     </Reference>
   </ItemGroup>
 
   <ItemGroup>
     <Reference Include="UnsupportedTypes">
-      <HintPath>$(ArtifactsBinDir)\UnsupportedTypes\$(Configuration)\net472\UnsupportedTypes.dll</HintPath>
+      <HintPath>$(ArtifactsBinDir)\UnsupportedTypes\$(Configuration)\$(NetFxTFM)\UnsupportedTypes.dll</HintPath>
     </Reference>
   </ItemGroup>